BACE. Lead Target for Orchestrated Therapy of Alzheimers Disease

BACE inhibitors and their use in the treatment of Alzheimers Disease BACE (β-site of APP cleaving enzyme) is a critical component in Alzheimers Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimers Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery. This book details the story of the discovery of BACE and its role in AD and comprehensively discusses: The development of BACE inhibitors as therapeutics for Alzheimers disease The research that led to the identification of BACE New BACE inhibitors currently being clinically tested ADME (absorption, distribution, metabolism, excretion) and clinical trial design—topics not addressed in current field literature Cutting-edge technology such as high-throughput screening, structure-based drug design, and QSAR in context of BACE inhibitors and Alzheimers drug discovery Other approaches to BACE inhibition based on interaction with the precursor protein APP By enhancing the readers understanding of the various aspects of the BACE drug-discovery process, this much-needed reference will serve as a key resource for all scientists involved in Alzheimers research—and inspire new approaches to treatment of AD.